Incidence of hepatocellular carcinoma and associated risk factors in hepatitis C-related advanced liver disease.

ABSTRACT:

Background & aims

Although the incidence of hepatocellular carcinoma (HCC) is increasing in the United States, data from large prospective studies are limited. We evaluated the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) cohort for the incidence of HCC and associated risk factors.

Methods

Hepatitis C virus-positive patients with bridging fibrosis or cirrhosis who did not respond to peginterferon and ribavirin were randomized to groups that were given maintenance peginterferon for 3.5 years or no treatment. HCC incidence was determined by Kaplan-Meier analysis, and baseline factors associated with HCC were analyzed by Cox regression.

Results

1,005 patients (mean age, 50.2 years; 71% male; 72% white race) were studied; 59% had bridging fibrosis,

SUBMITTER: Lok AS 

PROVIDER: S-EPMC3749922 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature