Model-based analysis of HER activation in cells co-expressing EGFR, HER2 and HER3.

ABSTRACT: The HER/ErbB family of receptor tyrosine kinases drives critical responses in normal physiology and cancer, and the expression levels of the various HER receptors are critical determinants of clinical outcomes. HER activation is driven by the formation of various dimer complexes between members of this receptor family. The HER dimer types can have differential effects on downstream signaling and phenotypic outcomes. We constructed an integrated mathematical model of HER activation, and trafficking to quantitatively link receptor expression levels to dimerization and activation. We parameterized the model with a comprehensive set of HER phosphorylation and abundance data collected in a panel of human mammary epithelial cells expressing varying levels of EGFR/HER1, HER2 and HER3. Although pa

SUBMITTER: Shankaran H 

PROVIDER: S-EPMC3749947 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature