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Nuclear hormone receptor regulation of microRNAs controls innate immune responses in C. elegans.

ABSTRACT: Nuclear hormone receptors respond to small molecules such as retinoids or steroids and regulate development. Signaling in the conserved p38/PMK-1 MAP kinase pathway regulates innate immunity. In this study, we show that the Caenorhabditis elegans nuclear receptor DAF-12 negatively regulates the defense against pathogens via the downstream let-7 family of microRNAs, which directly target SKN-1, a gene downstream of PMK-1. These findings identify nuclear hormone receptors as components of innate immunity that crosstalk with the p38/PMK-1 MAP kinase pathway.

SUBMITTER: Liu F

PROVIDER: S-EPMC3749966 | biostudies-literature |

REPOSITORIES: biostudies-literature

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