Evolutionary history and phylogeography of rabies viruses associated with outbreaks in Trinidad.

ABSTRACT: Bat rabies is an emerging disease of public health significance in the Americas. The Caribbean island of Trinidad experiences periodic outbreaks within the livestock population. We performed molecular characterisation of Trinidad rabies virus (RABV) and used a Bayesian phylogeographic approach to investigate the extent to which outbreaks are a result of in situ evolution versus importation of virus from the nearby South American mainland. Trinidadian RABV sequences were confirmed as bat variant and clustered with Desmodus rotundus (vampire bat) related sequences. They fell into two largely temporally defined lineages designated Trinidad I and II. The Trinidad I lineage which included sequences from 1997-2000 (all but two of which were from the northeast of the island) was most closely rela

SUBMITTER: Seetahal JF 

PROVIDER: S-EPMC3749974 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature