MNS16A tandem repeats minisatellite of human telomerase gene and cancer risk: a meta-analysis.

ABSTRACT:

Background

Researchers have provided evidence that telomere dysfunction play an important role in cancer development. MNS16A is a polymorphic tandem repeats minisatellite of human telomerase (hTERT) gene that influences promoter activity of hTERT and thus implicates to relate with risk of several malignancies. However, results on association between MNS16A and cancer risk remain controversial. We therefore conduct a meta-analysis to derive a more precise estimation of association between MNS16A and cancer risk.

Methods

A systematic literature search was conducted by searching PubMed, ISI Web of Knowledge, Human Genome and Epidemiology Network Navigator and Google Scholar digital database for publications on associations between MNS16A and cancer risk. Variants with statistic

SUBMITTER: Xia X 

PROVIDER: S-EPMC3750000 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature