Ensemble-based prediction of RNA secondary structures.

ABSTRACT:

Background

Accurate structure prediction methods play an important role for the understanding of RNA function. Energy-based, pseudoknot-free secondary structure prediction is one of the most widely used and versatile approaches, and improved methods for this task have received much attention over the past five years. Despite the impressive progress that as been achieved in this area, existing evaluations of the prediction accuracy achieved by various algorithms do not provide a comprehensive, statistically sound assessment. Furthermore, while there is increasing evidence that no prediction algorithm consistently outperforms all others, no work has been done to exploit the complementary strengths of multiple approaches.

Results

In this work, we present two contributions to th

SUBMITTER: Aghaeepour N 

PROVIDER: S-EPMC3750279 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature