Computational genetic neuroanatomy of the developing mouse brain: dimensionality reduction, visualization, and clustering.

ABSTRACT:

Background

The structured organization of cells in the brain plays a key role in its functional efficiency. This delicate organization is the consequence of unique molecular identity of each cell gradually established by precise spatiotemporal gene expression control during development. Currently, studies on the molecular-structural association are beginning to reveal how the spatiotemporal gene expression patterns are related to cellular differentiation and structural development.

Results

In this article, we aim at a global, data-driven study of the relationship between gene expressions and neuroanatomy in the developing mouse brain. To enable visual explorations of the high-dimensional data, we map the in situ hybridization gene expression data to a two-dimensional space b

SUBMITTER: Ji S 

PROVIDER: S-EPMC3750329 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature