Correlated mRNAs and miRNAs from co-expression and regulatory networks affect porcine muscle and finally meat properties.

ABSTRACT:

Background

Physiological processes aiding the conversion of muscle to meat involve many genes associated with muscle structure and metabolic processes. MicroRNAs regulate networks of genes to orchestrate cellular functions, in turn regulating phenotypes.

Results

We applied weighted gene co-expression network analysis to identify co-expression modules that correlated to meat quality phenotypes and were highly enriched for genes involved in glucose metabolism, response to wounding, mitochondrial ribosome, mitochondrion, and extracellular matrix. Negative correlation of miRNA with mRNA and target prediction were used to select transcripts out of the modules of trait-associated mRNAs to further identify those genes that are correlated with post mortem traits.

Conclusions

SUBMITTER: Ponsuksili S 

PROVIDER: S-EPMC3750351 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature