Linking environmental variability to village-scale malaria transmission using a simple immunity model.

ABSTRACT:

Background

Individuals continuously exposed to malaria gradually acquire immunity that protects from severe disease and high levels of parasitization. Acquired immunity has been incorporated into numerous models of malaria transmission of varying levels of complexity (e.g. Bull World Health Organ 50:347, 1974; Am J Trop Med Hyg 75:19, 2006; Math Biosci 90:385-396, 1988). Most such models require prescribing inputs of mosquito biting rates or other entomological or epidemiological information. Here, we present a model with a novel structure that uses environmental controls of mosquito population dynamics to simulate the mosquito biting rates, malaria prevalence as well as variability in protective immunity of the population.

Methods

A simple model of acquired immunity to mala

SUBMITTER: Yamana TK 

PROVIDER: S-EPMC3750354 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature