Cigarette smoke induces epithelial to mesenchymal transition and increases the metastatic ability of breast cancer cells.

ABSTRACT:

Background

Recent epidemiological studies demonstrate that both active and involuntary exposure to tobacco smoke increase the risk of breast cancer. Little is known, however, about the molecular mechanisms by which continuous, long term exposure to tobacco smoke contributes to breast carcinogenesis because most previous studies have focused on short term treatment models. In this work we have set out to investigate the progressive transforming effects of tobacco smoke on non-tumorigenic mammary epithelial cells and breast cancer cells using in vitro and in vivo models of chronic cigarette smoke exposure.

Results

We show that both non-tumorigenic (MCF 10A, MCF-12A) and tumorigenic (MCF7) breast epithelial cells exposed to cigarette smoke acquire mesenchymal properties such as

SUBMITTER: Di Cello F 

PROVIDER: S-EPMC3750372 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature