Body mass index affects proliferation and osteogenic differentiation of human subcutaneous adipose tissue-derived stem cells.

ABSTRACT:

Background

Obesity is associated with a higher risk of developing cancer and co-morbidities that are part of the metabolic syndrome. Adipose tissue is recognized as an endocrine organ, as it affects a number of physiological functions, and contains adipose tissue-derived stem cells (ASCs). ASCs can differentiate into cells of multiple lineages, and as such are applicable to tissue engineering and regenerative medicine. Yet the question of whether ASC functionality is affected by the donor's body mass index (BMI) still exists.

Results

ASCs were isolated from patients having different BMIs (BMI-ASCs), within the ranges of 18.5-32.8. It was hypothesized that overweight BMI-ASCs would be more compromised in early adipogenic and osteogenic potential, and ability to form colonies

SUBMITTER: Frazier TP 

PROVIDER: S-EPMC3750383 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature