Chronic airway-induced allergy in mice modifies gene expression in the brain toward insulin resistance and inflammatory responses.

ABSTRACT:

Background

Chronic systemic inflammation affects brain functionality and may negatively influence the progression of neurodegenerative disorders. Allergy is a chronic inflammatory disease affecting more than 20% of the Western population. Little is known regarding the influence of allergy on brain functions. The aim of the present study was to obtain a global overview of the genes that drive the effects of peripheral inflammation associated with chronic airway-induced allergy in the brain.

Methods

Airway allergy was induced in C57B/6J mice using ovalbumin as the allergen. Microarray analysis was performed in the hippocampus and frontal cortex in association with Affymetrix. For the data analysis, principal component analysis and orthogonal to latent structures discriminant a

SUBMITTER: Sarlus H 

PROVIDER: S-EPMC3750454 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature