The effective application of a discrete transition model to explore cell-cycle regulation in yeast.

ABSTRACT:

Background

Bench biologists often do not take part in the development of computational models for their systems, and therefore, they frequently employ them as "black-boxes". Our aim was to construct and test a model that does not depend on the availability of quantitative data, and can be directly used without a need for intensive computational background.

Results

We present a discrete transition model. We used cell-cycle in budding yeast as a paradigm for a complex network, demonstrating phenomena such as sequential protein expression and activity, and cell-cycle oscillation. The structure of the network was validated by its response to computational perturbations such as mutations, and its response to mating-pheromone or nitrogen depletion. The model has a strong predicati

SUBMITTER: Rubinstein A 

PROVIDER: S-EPMC3750494 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature