Characterization of aberrant pathways across human cancers.

ABSTRACT:

Background

Cancer is a broad group of genetic diseases which account for millions of deaths worldwide each year. Cancers are classified by various clinical, pathological and molecular methods, but even within a well-characterized disease, there is a significant inter-patient variability in survival, response to treatment, and other parameters. Especially in molecular level, tumours of the same category can appear significantly dissimilar due to complex combinations of genetic aberrations leading to a similar malignancy. We extended the current classification methods by studying tumour heterogeneity at pathway level.

Methods

We computed the rate of alterations in 1994 pathways and 2210 tumours consisting of eight different cancers. Using gene set enrichment analysis, each sam

SUBMITTER: Ylipaa A 

PROVIDER: S-EPMC3750561 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature