Bone marrow-derived progenitor cells in end-stage lung disease patients.

ABSTRACT:

Background

Chronic lung diseases are marked by progressive inflammation, tissue damage and remodelling. Bone marrow-derived progenitor cells may contribute to these processes. The objectives of this study were to (1) to quantify CD45⁺Collagen-1⁺ fibrocytes and a novel epithelial-like population of bone marrow-derived cells, which express Clara Cell Secretory Protein, in patients at the time of lung transplant and (2) to evaluate mediators that may act to recruit these cells during injury.

Methods

Using an observational design, progenitor cells were quantified by flow cytometry from both bone marrow (BM) and peripheral blood (PB). Migration was tested using in vitro transwell assays. Multiplex bead-based assays were used to quantify plasma cytokines.

Results

An increas

SUBMITTER: Gilpin SE 

PROVIDER: S-EPMC3750607 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature