USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy.

ABSTRACT: Reversible protein ubiquitination is emerging as a key process for maintaining cell homeostasis, and the enzymes that participate in this process, in particular E3 ubiquitin ligases and deubiquitinases (DUBs), are increasingly being regarded as candidates for drug discovery. Human DUBs are a group of approximately 100 proteins, whose cellular functions and regulatory mechanisms remain, with some exceptions, poorly characterized. One of the best-characterized human DUBs is ubiquitin-specific protease 1 (USP1), which plays an important role in the cellular response to DNA damage. USP1 levels, localization and activity are modulated through several mechanisms, including protein-protein interactions, autocleavage/degradation and phosphorylation, ensuring that USP1 function is carried out in a

SUBMITTER: Garcia-Santisteban I 

PROVIDER: S-EPMC3750636 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature