Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension.

ABSTRACT:

Context

A previous study reported a gene x environment interaction in which a haplotype in the corticotropin-releasing hormone receptor 1 gene (CRHR1) was associated with protection against adult depressive symptoms in individuals who were maltreated as children (as assessed by the Childhood Trauma Questionnaire [CTQ]).

Objective

To replicate the interaction between childhood maltreatment and a TAT haplotype formed by rs7209436, rs110402, and rs242924 in CRHR1, predicting adult depression.

Design

Two prospective longitudinal cohort studies.

Setting

England and New Zealand.

Participants

Participants in the first sample were women in the E-Risk Study (N = 1116), followed up to age 40 years with 96% retention. Participants in the second sample were men and

SUBMITTER: Polanczyk G 

PROVIDER: S-EPMC3750953 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature