A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus release.

ABSTRACT:

Background

Tetherin (or BST-2) is an antiviral host restriction factor that suppresses the release of HIV-1 and other enveloped viruses by tethering them to the cell surface. Recently, it has been demonstrated that tetherin also acts as an innate sensor of HIV-1 assembly that induces NF-κB-dependent proinflammatory responses. Furthermore, it has been reported that polymorphisms in the promoter and 3' untranslated region of the bst2 gene may affect the clinical outcome of HIV-1 infection. However, non-synonymous polymorphisms in the bst2 open reading frame have not yet been described or functionally characterized.

Results

Mining of the Exome Variant Server database identified seven very rare naturally occurring missense variants of tetherin (Y8H, R19H, N49S, D103N, E117A, D12

SUBMITTER: Sauter D 

PROVIDER: S-EPMC3751106 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature