Transcriptional profiling reveals progeroid Ercc1(-/Δ) mice as a model system for glomerular aging.

ABSTRACT:

Background

Aging-related kidney diseases are a major health concern. Currently, models to study renal aging are lacking. Due to a reduced life-span progeroid models hold the promise to facilitate aging studies and allow examination of tissue-specific changes. Defects in genome maintenance in the Ercc1(-/Δ) progeroid mouse model result in premature aging and typical age-related pathologies. Here, we compared the glomerular transcriptome of young and aged Ercc1-deficient mice to young and aged WT mice in order to establish a novel model for research of aging-related kidney disease.

Results

In a principal component analysis, age and genotype emerged as first and second principal components. Hierarchical clustering of all 521 genes differentially regulated between young and old

SUBMITTER: Schermer B 

PROVIDER: S-EPMC3751413 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature