Analysis of genes that encode DtxR-like transcriptional regulators in pathogenic and saprophytic corynebacterial species.

ABSTRACT: Metal-dependent transcriptional regulators of the diphtheria toxin repressor (DtxR) family have been identified in a wide variety of bacterial genera, where they control gene expression in response to one of two metal ions, Fe(2+) or Mn(2+). DtxR of Corynebacterium diphtheriae is the best characterized of these important metal-dependent regulators. The genus Corynebacterium includes many phenotypically diverse species, and the prevalence of DtxR-like regulators within the genus is unknown. We assayed chromosomal DNA from 42 different corynebacterial isolates, representing 33 different species, for the presence of a highly conserved region of the dtxR gene that encodes the DNA-binding helix-turn-helix motif and metal-binding site 1 within domains 1 and 2 of DtxR. The chromosome of all of th

SUBMITTER: Oram DM 

PROVIDER: S-EPMC375144 | biostudies-literature | 2004 Apr

REPOSITORIES: biostudies-literature