Inhibition of astroglial NF-κB enhances oligodendrogenesis following spinal cord injury.

ABSTRACT:

Background

Astrocytes are taking the center stage in neurotrauma and neurological diseases as they appear to play a dominant role in the inflammatory processes associated with these conditions. Previously, we reported that inhibiting NF-κB activation in astrocytes, using a transgenic mouse model (GFAP-IκBα-dn mice), results in improved functional recovery, increased white matter preservation and axonal sparing following spinal cord injury (SCI). In the present study, we sought to determine whether this improvement, due to inhibiting NF-κB activation in astrocytes, could be the result of enhanced oligodendrogenesis in our transgenic mice.

Methods

To assess oligodendrogenesis in GFAP-IκBα-dn compared to wild-type (WT) littermate mice following SCI, we used bromodeoxyuridine la

SUBMITTER: Bracchi-Ricard V 

PROVIDER: S-EPMC3751509 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature