Global transcriptional response of Caulobacter crescentus to iron availability.

ABSTRACT:

Background

In the alpha subclass of proteobacteria iron homeostasis is controlled by diverse iron responsive regulators. Caulobacter crescentus, an important freshwater α-proteobacterium, uses the ferric uptake repressor (Fur) for such purpose. However, the impact of the iron availability on the C. crescentus transcriptome and an overall perspective of the regulatory networks involved remain unknown.

Results

In this work we report the identification of iron-responsive and Fur-regulated genes in C. crescentus using microarray-based global transcriptional analyses. We identified 42 genes that were strongly upregulated both by mutation of fur and by iron limitation condition. Among them, there are genes involved in iron uptake (four TonB-dependent receptor gene clusters, and fe

SUBMITTER: da Silva Neto JF 

PROVIDER: S-EPMC3751524 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature