Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor.

ABSTRACT:

Background

The FHIT tumor suppressor gene is arguably the most commonly altered gene in cancer since it is inactivated in about 60% of human tumors. The Fhit protein is a member of the ubiquitous histidine triad proteins which hydrolyze dinucleoside polyphosphates such as Ap3A. Despite the fact that Fhit functions as a tumor suppressor, the pathway through which Fhit inhibits growth of cancer cells remains largely unknown. Phosphorylation by Src tyrosine kinases provides a linkage between Fhit and growth factor signaling. Since many G proteins can regulate cell proliferation through multiple signaling components including Src, we explored the relationship between Gα subunits and Fhit.

Results

Several members of the Gαq subfamily (Gα16, Gα14, and Gαq) were found to co-immunop

SUBMITTER: Zuo H 

PROVIDER: S-EPMC3751744 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature