Molecular signatures of mammalian hibernation: comparisons with alternative phenotypes.

ABSTRACT:

Background

Mammalian hibernators display phenotypes similar to physiological responses to calorie restriction and fasting, sleep, cold exposure, and ischemia-reperfusion in non-hibernating species. Whether biochemical changes evident during hibernation have parallels in non-hibernating systems on molecular and genetic levels is unclear.

Results

We identified the molecular signatures of torpor and arousal episodes during hibernation using a custom-designed microarray for the Arctic ground squirrel (Urocitellus parryii) and compared them with molecular signatures of selected mouse phenotypes. Our results indicate that differential gene expression related to metabolism during hibernation is associated with that during calorie restriction and that the nuclear receptor protein PP

SUBMITTER: Xu Y 

PROVIDER: S-EPMC3751779 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature