Core modular blood and brain biomarkers in social defeat mouse model for post traumatic stress disorder.

ABSTRACT:

Background

Post-traumatic stress disorder (PTSD) is a severe anxiety disorder that affects a substantial portion of combat veterans and poses serious consequences to long-term health. Consequently, the identification of diagnostic and prognostic blood biomarkers for PTSD is of great interest. Previously, we assessed genome-wide gene expression of seven brain regions and whole blood in a social defeat mouse model subjected to various stress conditions.

Results

To extract biological insights from these data, we have applied a new computational framework for identifying gene modules that are activated in common across blood and various brain regions. Our results, in the form of modular gene networks that highlight spatial and temporal biological functions, provide a systems-lev

SUBMITTER: Yang R 

PROVIDER: S-EPMC3751782 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature