Longitudinal transcriptomic dysregulation in the peripheral blood of transgenic Huntington's disease monkeys.

ABSTRACT:

Background

Huntington's Disease (HD) is a progressive neurodegenerative disorder caused by an expansion in the polyglutamine (polyQ) region of the Huntingtin (HTT) gene. The clinical features of HD are characterized by cognitive, psychological, and motor deficits. Molecular instability, a core component in neurological disease progression, can be comprehensively evaluated through longitudinal transcriptomic profiling. Development of animal models amenable to longitudinal examination enables distinct disease-associated mechanisms to be identified.

Results

Here we report the first longitudinal study of transgenic monkeys with genomic integration of various lengths of the human HTT gene and a range of polyQ repeats. With this unique group of transgenic HD nonhuman primates (HD

SUBMITTER: Kocerha J 

PROVIDER: S-EPMC3751855 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature