Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells.

ABSTRACT:

Background

Chromosome instability manifests as an abnormal chromosome complement and is a pathogenic event in cancer. Although a correlation between abnormal chromosome numbers and cancer exist, the underlying mechanisms that cause chromosome instability are poorly understood. Recent data suggests that aberrant sister chromatid cohesion causes chromosome instability and thus contributes to the development of cancer. Cohesion normally functions by tethering nascently synthesized chromatids together to prevent premature segregation and thus chromosome instability. Although the prevalence of aberrant cohesion has been reported for some solid tumors, its prevalence within liquid tumors is unknown. Consequently, the current study was undertaken to evaluate aberrant cohesion within Hodgk

SUBMITTER: Sajesh BV 

PROVIDER: S-EPMC3751861 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature