Genetic variability of mutans streptococci revealed by wide whole-genome sequencing.

ABSTRACT:

Background

Mutans streptococci are a group of bacteria significantly contributing to tooth decay. Their genetic variability is however still not well understood.

Results

Genomes of 6 clinical S. mutans isolates of different origins, one isolate of S. sobrinus (DSM 20742) and one isolate of S. ratti (DSM 20564) were sequenced and comparatively analyzed. Genome alignment revealed a mosaic-like structure of genome arrangement. Genes related to pathogenicity are found to have high variations among the strains, whereas genes for oxidative stress resistance are well conserved, indicating the importance of this trait in the dental biofilm community. Analysis of genome-scale metabolic networks revealed significant differences in 42 pathways. A striking dissimilarity is the unique pr

SUBMITTER: Song L 

PROVIDER: S-EPMC3751929 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature