RNA in blood is altered prior to hemorrhagic transformation in ischemic stroke.

ABSTRACT:

Objective

Hemorrhagic transformation (HT) is a major complication of ischemic stroke that worsens outcomes and increases mortality. Disruption of the blood-brain barrier is a central feature of HT pathogenesis, and leukocytes may contribute to this process. We sought to determine whether ischemic strokes that develop HT have differences in RNA expression in blood within 3 hours of stroke onset prior to treatment with thrombolytic therapy.

Methods

Stroke patient blood samples were obtained prior to treatment with thrombolysis, and leukocyte RNA was assessed by microarray analysis. Strokes that developed HT (n = 11) were compared to strokes without HT (n = 33) and controls (n = 14). Genes were identified (corrected p < 0.05, fold change ≥|1.2|), and functional analysis was per

SUBMITTER: Jickling GC 

PROVIDER: S-EPMC3752310 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature