A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.

ABSTRACT: Several studies have identified genes associated with alcohol-use disorders (AUDs), but the variation in each of these genes explains only a small portion of the genetic vulnerability. The goal of the present study was to perform a genome-wide association study (GWAS) in extended families from the Collaborative Study on the Genetics of Alcoholism to identify novel genes affecting risk for alcohol dependence (AD). To maximize the power of the extended family design, we used a quantitative endophenotype, measured in all individuals: number of alcohol-dependence symptoms endorsed (symptom count (SC)). Secondary analyses were performed to determine if the single nucleotide polymorphisms (SNPs) associated with SC were also associated with the dichotomous phenotype, DSM-IV AD. This family-based

SUBMITTER: Wang JC 

PROVIDER: S-EPMC3752321 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature