HIV-1 decreases the levels of neurotrophins in human lymphocytes.
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ABSTRACT:
SUBMITTER: Avdoshina V
PROVIDER: S-EPMC3752340 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Publications
HIV-1 decreases the levels of neurotrophins in human lymphocytes.
Avdoshina Valeriya V Garzino-Demo Alfredo A Bachis Alessia A Monaco Maria C G MC Maki Pauline M PM Tractenberg Rochelle E RE Liu Chenglong C Young Mary A MA Mocchetti Italo I
AIDS (London, England) 20110501 8
Neurotrophins control cell survival. Therefore, we examined whether HIV-1 reduces neurotrophin levels. Serum of HIV-positive individuals exhibited lower concentrations of brain-derived neurotrophic factor (BDNF), but not of other neurotrophins, than HIV-negative individuals. In addition, R5 and X4 strains of HIV-1 decreased BDNF expression in T cells. Our results support the hypothesis that reduced levels of BDNF may be a risk factor for T-cell apoptosis and for neurological complications associ ...[more]
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