Association between hTERT rs2736100 polymorphism and sensitivity to anti-cancer agents.

ABSTRACT:

Background

The rs2736100 single nucleotide polymorphism (SNP) is located in the intron 2 of human telomerase reverse transcriptase (hTERT) gene. Recent genome-wide association studies (GWAS) have consistently supported the strong association between this SNP and risk for multiple cancers. Given the important role of the hTERT gene and this SNP in cancer biology, we hypothesize that rs2736100 may also confer susceptibility to anti-cancer drug sensitivity. In this study we aim to investigate the correlation between the rs2736100 genotype and the responsiveness to anti-cancer agents in the NCI-60 cancer cell panel.

Methods and materials

The hTERT rs2736100 was genotyped in the NCI-60 cancer cell lines. The relative telomere length (RTL) of each cell line was quantified using re

SUBMITTER: Kim J 

PROVIDER: S-EPMC3752523 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature