Reprogramming of mesenchymal stem cells by the synovial sarcoma-associated oncogene SYT-SSX2.

ABSTRACT: Cell identity is determined by its gene expression programs. The ability of a cell to change its identity and produce cell types outside its lineage is achieved by the activity of transcription controllers capable of reprogramming differentiation gene networks. The synovial sarcoma (SS)-associated protein, SYT-SSX2, reprograms myogenic progenitors and human bone marrow-derived mesenchymal stem cells (BMMSCs) by dictating their commitment to a pro-neural lineage. It fulfills this function by directly targeting an extensive array of neural-specific genes as well as genes of developmental pathway mediators. Concomitantly, the ability of both myoblasts and BMMSCs to differentiate into their normal myogenic and adipogenic lineages was compromised. SS is believed to arise in mesenchymal stem cel

SUBMITTER: Garcia CB 

PROVIDER: S-EPMC3752676 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature