Embryonal central nervous system neoplasms arising in infants and young children: a pediatric brain tumor consortium study.

ABSTRACT:

Context

Medulloblastomas (MBs) and atypical teratoid/rhabdoid tumors (AT/RTs) arising in infants and children can be difficult to distinguish; however, histologic characterization is prognostically important.

Objective

To determine histologic and phenotypic markers associated with utility with progression-free survival (PFS) and overall survival (OS) in children younger than 3 years with MBs and AT/RTs.

Design

We undertook a histologic and immunophenotypic study of MBs and AT/RTs arising in infants and children younger than 3 years treated in a Pediatric Brain Tumor Consortium study. The 41 girls and 55 boys ranged in age from 2 to 36 months at enrollment. These infants and children exhibited 51 MBs, 26 AT/RTs, and 24 other tumors (not further studied). Median follow-

SUBMITTER: McLendon RE 

PROVIDER: S-EPMC3752842 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature