Neural primacy of the salience processing system in schizophrenia.
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ABSTRACT:
SUBMITTER: Palaniyappan L
PROVIDER: S-EPMC3752973 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Neural primacy of the salience processing system in schizophrenia.
Palaniyappan Lena L Simmonite Molly M White Thomas P TP Liddle Elizabeth B EB Liddle Peter F PF
Neuron 20130801 4
For effective information processing, two large-scale distributed neural networks appear to be critical: a multimodal executive system anchored on the dorsolateral prefrontal cortex (DLPFC) and a salience system anchored on the anterior insula. Aberrant interaction among distributed networks is a feature of psychiatric disorders such as schizophrenia. We used whole-brain Granger causal modeling using resting fMRI and observed a significant failure of both the feedforward and reciprocal influence ...[more]
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