Dataset Information

Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.

ABSTRACT:

Objectives

This study sought to determine whether variations in NOS1AP affect drug-induced long QT syndrome (LQTS).

Background

Use of antiarrhythmic drugs is limited by the high incidence of serious adverse events including QT prolongation and torsades de pointes. NOS1AP gene variants play a role in modulating QT intervals in healthy subjects and severity of presentation in LQTS.

Methods

This study carried out an association study using 167 single nucleotide polymorphisms (SNP) spanning the NOS1AP gene in 58 Caucasian patients experiencing drug-induced LQTS (dLQTS) and 87 Caucasian controls from the DARE (Drug-Induced Arrhythmia Risk Evaluation) study.