Graft-related disease progression in dura mater graft-associated Creutzfeldt-Jakob disease: a cross-sectional study.

ABSTRACT:

Objectives

Details of abnormal prion protein (PrP(Sc)) propagation in the human central nervous system (CNS) are unclear. To assess the spread of PrP(Sc) through the human CNS, we evaluated dura mater graft-associated Creutzfeldt-Jakob disease (dCJD) cases focusing on sites of grafting and dCJD pathological subtypes.

Design

A cross-sectional study.

Setting

nationwide surveillance data of human prion diseases in Japan over the past 12 years were applied for the study.

Participants

Clinical data were obtained from 84 dCJD patients.

Outcome measures

The clinical courses in cases of dCJD were analysed according to the grafting sites (supratentorial and infratentorial groups) and the pathological subtypes (non-plaque and plaque types).

Results

Of the 8

SUBMITTER: Sakai K 

PROVIDER: S-EPMC3753481 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature