Genome-wide survey of DNA-binding proteins in Arabidopsis thaliana: analysis of distribution and functions.

ABSTRACT: The interaction of proteins with their respective DNA targets is known to control many high-fidelity cellular processes. Performing a comprehensive survey of the sequenced genomes for DNA-binding proteins (DBPs) will help in understanding their distribution and the associated functions in a particular genome. Availability of fully sequenced genome of Arabidopsis thaliana enables the review of distribution of DBPs in this model plant genome. We used profiles of both structure and sequence-based DNA-binding families, derived from PDB and PFam databases, to perform the survey. This resulted in 4471 proteins, identified as DNA-binding in Arabidopsis genome, which are distributed across 300 different PFam families. Apart from several plant-specific DNA-binding families, certain RING fingers and

SUBMITTER: Malhotra S 

PROVIDER: S-EPMC3753632 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature