Histologic markers of inflammation in patients with ulcerative colitis in clinical remission.

ABSTRACT:

Background & aims

Mucosal healing, based on histologic analysis, is an end point of maintenance therapy for patients with ulcerative colitis (UC). There are few data on how histologic signs of inflammation correlate with endoscopic and peripheral blood measures of inflammation in these patients. We investigated patterns of histologic features of inflammation in patients with UC in clinical remission, and correlated these with endoscopic and biochemical measures of inflammation.

Methods

We performed a prospective observational study of 103 patients with UC in clinical remission undergoing surveillance colonoscopy while receiving maintenance therapy with mesalamine or thiopurines; 2674 biopsy specimens were collected from 708 colonic segments. Each colonic segment was evaluate

SUBMITTER: Rosenberg L 

PROVIDER: S-EPMC3753658 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature