Palladium-catalyzed asymmetric conjugate addition of arylboronic acids to heterocyclic acceptors.

ABSTRACT: Flava Flavanone: Asymmetric conjugate additions to chromones and 4-quinolones are reported utilizing a single catalyst system formed in situ from Pd(OCOCF(3))(2) and (S)-tBuPyOX. Notably, these reactions are performed in wet solvent under ambient atmosphere, and employ readily available arylboronic acids as the nucleophile, thus providing ready access to these asymmetric heterocycles (see scheme).

SUBMITTER: Holder JC 

PROVIDER: S-EPMC3753812 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature