Inverse relationship between body mass index and coronary artery calcification in patients with clinically significant coronary lesions.

ABSTRACT:

Aims

Mounting data support a 'calcification paradox', whereby reduced bone mineral density is associated with increased vascular calcification. Furthermore, reduced bone mineral density is prevalent in older persons with lower body mass index (BMI). Therefore, although BMI and coronary artery calcification (CAC) exhibit a positive relationship in younger persons, it is predicted that in older persons and/or those at risk for osteoporosis, an inverse relationship between BMI and CAC may apply. We sought to explore this hypothesis in a large group of patients with coronary artery disease undergoing percutaneous coronary intervention (PCI).

Methods and results

We accessed our single-center registry for 07/01/1999 to 06/30/2009, extracting data on all patients that underwent PCI

SUBMITTER: Kovacic JC 

PROVIDER: S-EPMC3753813 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature