Residue-level prediction of HIV-1 antibody epitopes based on neutralization of diverse viral strains.

ABSTRACT: Delineation of antibody epitopes at the residue level is key to understanding antigen resistance mutations, designing epitope-specific probes for antibody isolation, and developing epitope-based vaccines. Ideally, epitope residues are determined in the context of the atomic-level structure of the antibody-antigen complex, though structure determination may in many cases be impractical. Here we describe an efficient computational method to predict antibody-specific HIV-1 envelope (Env) epitopes at the residue level, based on neutralization panels of diverse viral strains. The method primarily utilizes neutralization potency data over a set of diverse viral strains representing the antigen, and enhanced accuracy could be achieved by incorporating information from the unbound structure of the

SUBMITTER: Chuang GY 

PROVIDER: S-EPMC3753990 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature