Acute-phase CD8 T cell responses that select for escape variants are needed to control live attenuated simian immunodeficiency virus.

ABSTRACT: The overall CD8 T cell response to human/simian immunodeficiency virus (HIV/SIV) targets a collection of discrete epitope specificities. Some of these epitope-specific CD8 T cells emerge in the weeks and months following infection and rapidly select for sequence variants, whereas other CD8 T cell responses develop during the chronic infection phase and rarely select for sequence variants. In this study, we tested the hypothesis that acute-phase CD8 T cell responses that do not rapidly select for escape variants are unable to control viral replication in vivo as well as those that do rapidly select for escape variants. We created a derivative of live attenuated SIV (SIVmac239Δnef) in which we ablated five epitopes that elicit early CD8 T cell responses and rapidly accumulate sequence varian

SUBMITTER: Harris M 

PROVIDER: S-EPMC3754066 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature