Nisin resistance of Listeria monocytogenes is increased by exposure to salt stress and is mediated via LiaR.

ABSTRACT: Growth of Listeria monocytogenes on refrigerated, ready-to-eat food is a significant food safety concern. Natural antimicrobials, such as nisin, can be used to control this pathogen on food, but little is known about how other food-related stresses may impact how the pathogen responds to these compounds. Prior work demonstrated that exposure of L. monocytogenes to salt stress at 7°C led to increased expression of genes involved in nisin resistance, including the response regulator liaR. We hypothesized that exposure to salt stress would increase subsequent resistance to nisin and that LiaR would contribute to increased nisin resistance. Isogenic deletion mutations in liaR were constructed in 7 strains of L. monocytogenes, and strains were exposed to 6% NaCl in brain heart infusion broth an

SUBMITTER: Bergholz TM 

PROVIDER: S-EPMC3754191 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature