Induction of rapid cell death by an environmental isolate of Legionella pneumophila in mouse macrophages.

ABSTRACT: Legionella pneumophila, the etiological agent for Legionnaires' disease, is ubiquitous in the aqueous environment, where it replicates as an intracellular parasite of free-living protozoa. Our understanding of L. pneumophila pathogenicity is obtained mostly from study of derivatives of several clinical isolates, which employ almost identical virulent determinants to exploit host functions. To determine whether environmental L. pneumophila isolates interact similarly with the model host systems, we analyzed intracellular replication of several recently isolated such strains and found that these strains cannot productively grow in bone marrow-derived macrophages of A/J mice, which are permissive for all examined laboratory strains. By focusing on one strain called LPE509, we found that its d

SUBMITTER: Tao L 

PROVIDER: S-EPMC3754228 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature