A proposal for augmenting biological model construction with a semi-intelligent computational modeling assistant.

ABSTRACT: The translational challenge in biomedical research lies in the effective and efficient transfer of mechanistic knowledge from one biological context to another. Implicit in this process is the establishment of causality from correlation in the form of mechanistic hypotheses. Effectively addressing the translational challenge requires the use of automated methods, including the ability to computationally capture the dynamic aspect of putative hypotheses such that they can be evaluated in a high throughput fashion. Ontologies provide structure and organization to biomedical knowledge; converting these representations into executable models/simulations is the next necessary step. Researchers need the ability to map their conceptual models into a model specification that can be transformed int

SUBMITTER: Christley S 

PROVIDER: S-EPMC3754423 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature