Genetic risk factors for Clostridium difficile infection in ulcerative colitis.

ABSTRACT:

Background

Patients with inflammatory bowel disease (IBD) are at higher risk for Clostridium difficile infection (CDI). Disruption of gut microbiome and interaction with the intestinal immune system are essential mechanisms for pathogenesis of both CDI and IBD. Whether genetic polymorphisms associated with susceptibility to IBD are also associated with risk of CDI is unknown.

Aims

To use a well-characterised and genotyped cohort of patients with UC to (i) identify clinical risk factors for CDI; (ii) examine if any of the IBD genetic risk loci were associated with CDI; and (iii) to compare the performance of predictive models using clinical and genetic risk factors in determining risk of CDI.

Methods

We used a prospective registry of patients from a tertiary referral h

SUBMITTER: Ananthakrishnan AN 

PROVIDER: S-EPMC3755009 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature