Expression of neuropeptides and cytokines in a rabbit model of diabetic neuroischemic wound healing.

ABSTRACT:

Objective

The present study is designed to understand the contribution of peripheral vascular disease and peripheral neuropathy to the wound-healing impairment associated with diabetes. Using a rabbit model of diabetic neuroischemic wound healing, we investigated rate of healing, leukocyte infiltration, and expression of cytokines, interleukin-8 and interleukin-6, and neuropeptides, substance P, and neuropeptide Y.

Methods

Diabetes was induced in New Zealand White rabbits by administering alloxan while control rabbits received saline. Ten days later, animals in both groups underwent surgery. One ear served as a sham, and the other was made ischemic (ligation of central+rostral arteries) or neuroischemic (ischemia+ resection of central+rostral nerves). Four 6-mm punch biopsy

SUBMITTER: Pradhan Nabzdyk L 

PROVIDER: S-EPMC3755034 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature