A simple and reproducible prognostic index in luminal ER-positive breast cancers.

ABSTRACT:

Background

The group of estrogen receptor (ER)-positive breast cancers (both luminal-A and -B) behaves differently from the ER-negative group. At least in early follow-up, ER expression influences positively patients' prognosis. This low aggressive biology flattens out the differences of clinical management. Thus we aimed to produce a prognostic index specific for ER-positive (ERPI) cancers that could be of aid for clinical decision.

Patients and methods

The test set comprised 495 consecutive ER-positive breast cancers. Tumor size, number of metastatic lymph nodes and androgen receptor expression were the only independent variables related to disease-specific survival. These variables were used to create the ERPI, which was applied to the entire test set and to selected subp

SUBMITTER: Castellano I 

PROVIDER: S-EPMC3755326 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature