A novel germline mutation in HOXB13 is associated with prostate cancer risk in Chinese men.

ABSTRACT:

Background

A rare mutation G84E in HOXB13 was recently identified to be associated with prostate cancer (PCa) in Caucasians. The goal of this study is to test association between HOXB13 genetic variants and PCa risk in Chinese men.

Methods

All study subjects were part of the Chinese Consortium for Prostate Cancer Genetics (ChinaPCa). In the first stage, we screened for mutations by sequencing the HOXB13 coding region in 96 unrelated PCa patients. In stage 2, G84E and novel mutations found in stage 1 were genotyped in 671 PCa patients and 1,536 controls. In stage 3, mutation status in 751 additional PCa patients was imputed via haplotype.

Results

The G84E mutation was not detected in this study. However, a novel mutation, G135E, was identified among 96 patients in stag

SUBMITTER: Lin X 

PROVIDER: S-EPMC3755486 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature